The race in its 15th year, but this is the first year Cancer Connection has taken over the event.
While Glacier Valley Rotary Club has sponsored the event in recent past years and given the revenue to Cancer Connection, non-profit group regulations make it difficult for one non-profit group to give funds to another.
This year the race has been given to the cancer support group, and Glacier Valley Rotary will provide volunteers at the event as a community service project.
Cancer Connection board president Tish Griffin Satre said both groups are excited about working together for the event, which has become a Juneau tradition.
With more than 400 participants expected at the event, Griffin Satre said the 2-mile walk and 5K run is truly a community affair.
The Southeast Alaska Roadrunners will supervise the actual race.
"It's one of the most empowering, exciting events of the year. It's very uplifting," she said.
The race is open to women and registration for the race is $20 per person and the money is used locally.
"It's a great way for Cancer Connection to build up some of the programs," Griffin Satre said. "The money all stays locally and helps your friends and neighbors."
The first 500 registered participants also receive a long-sleeved pink T-shirt, which Griffin Satre said is a coveted item.
"There are people who collect them and have them from all 15 years," she said.
"We're hoping people will register early and often, and it's brings folks together for a great cause."
Each year the race is follows a speaker who has had an experience with cancer.
This year's speaker is Juneau resident Joyce Parry Moore.
"We're excited to her kicking off the race," Griffin Satre said. "She has an amazing story to tell."
Virginia Smiley, Cancer Connection vice president and race coordinator, said she has participated for years to honor her mother who is a cancer survivor.
"I think it's one of the most well attended events in Juneau," Smiley said.
"It's a fun event. Come out for a long walk with 400 of your closest friends in Juneau."
Registration can be done at Foggy Mountain Shop, the Alaska Club, Nugget Alaska Outfitters or online at www.cancerconnectionak.org.